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Journal Article 89

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acute myeloid leukemia 9

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chronic kidney disease 4

biomarker 3

chronic hepatitis B 3

prognosis 3

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acute-on-chronic liver failure 2

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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 204-211 doi: 10.1007/s11684-012-0202-x

Abstract:

We evaluated the outcomes of chronic myeloid leukemia (CML) patients in three clinical phases, namely, chronic (CP), accelerated (AP), and blast (BP) phases, receiving imatinib treatment.

Keywords： imatinib     chronic myeloid leukemia     complete cytogenetic response    

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allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronicmyelogenous leukemia in the accelerated phase

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 304-311 doi: 10.1007/s11684-015-0400-4

Abstract:

In the tyrosine kinase inhibitor (TKI) era, imatinib is the first-line therapy for patients with chronicmyeloid leukemia (CML) in chronic or accelerated phase.

Keywords： chronic myeloid leukemia     imatinib     dasatinib     nilotinib     allogeneic hematopoietic stem cell transplantation    

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Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving

Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 344-353 doi: 10.1007/s11684-018-0639-7

Abstract: Dasatinib is a highly effective second-generation tyrosine kinase inhibitor used to treat chronic myeloidleukemia (CML).This report from the 4-year follow-up revealed that 73% of 59 patients in chronic phase (CML-CP) and

Keywords： chronic myeloid leukemia (CML)     dasatinib     tyrosine kinase inhibitor     long-term follow-up    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.categories, class I mutations that confer a proliferation advantage and class II mutations that inhibit myeloid

Keywords： acute myeloid leukemia     mutations     risk stratification    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: However, little is known about the role of ACSL5 in acute myeloid leukemia (AML).

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloidleukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 440-444 doi: 10.1007/s11684-017-0523-x

Abstract:

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguishfrom the blast phase of chronic myeloid leukemia.As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lyticfusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloidleukemia was made, although the type (de novo or blast crisis) remained unclear.

Keywords： Philadelphia chromosome     acute myeloid leukemia     mass     osteolysis     positron emission tomography    

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Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 667-679 doi: 10.1007/s11684-019-0702-z

Abstract: Chronic graft-versus-host disease (cGVHD) is a major complication following unmanipulated haploidenticalrisk factors for cGVHD in patients who underwent anti-thymocyte globulin-based haplo-HSCT for acute myeloidleukemia ( =280).

Keywords： acute graft-versus-host disease     chronic graft-versus-host disease     National Institutes of Health consensuscriteria     acute myeloid leukemia     anti-thymocyte globulin    

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Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 701-710 doi: 10.1007/s11684-020-0763-z

Abstract: Acute myeloid leukemia (AML) is a group of heterogeneous myeloid malignancies.Allogeneic hematopoietic stem cell transplantation could be an effective therapy because of the graft-versus-leukemia

Keywords： acute myeloid leukemia     CAR T     immunotherapy    

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Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloidleukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 593-599 doi: 10.1007/s11684-018-0635-y

Abstract: Conventional combination therapies have not resulted in considerable progress in the treatment of acute myeloidleukemia (AML).Venetoclax, a BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chroniclymphoid leukemia.

Keywords： venetoclax     cytarabine     AML     leukemia    

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The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

Jessica Fredericks, Ruibao Ren

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 452-461 doi: 10.1007/s11684-013-0304-0

Abstract:

BCR/ABL is the causative agent of chronic myelogenous leukemia (CML).

Keywords： BCR/ABL     chronic myelogenous leukemia (CML)     RAS     RAL    

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methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML).mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloidleukemia

Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang, Shuhong Shen

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 378-387 doi: 10.1007/s11684-018-0658-4

Abstract: exhibits a unique anticancer mechanism and has been widely used in China to treat patients with acute myeloidleukemia (AML) since the 1970s.2009 to November 2015, 59 patients less than 2 years old with AML (other than acute promyelocytic leukemia

Keywords： homoharringtonine     acute myeloid leukemia     pediatrics    

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Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 229-237 doi: 10.1007/s11684-018-0616-1

Abstract: retrospective analysis aimed to investigate the mutation profile of 16 common mutated genes in acute myeloidleukemia (AML) patients.

Keywords： leukemia     myeloid     acute     gene     mutation    

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Title Author Date Type Operation

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Journal Article

allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronicmyelogenous leukemia in the accelerated phase

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Journal Article

Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving

Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloidleukemia

Journal Article

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Journal Article

Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Journal Article

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Journal Article

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloidleukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Journal Article

The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

Jessica Fredericks, Ruibao Ren

Journal Article

methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloidleukemia

Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang, Shuhong Shen

Journal Article

Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Journal Article